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- Title
Palladium-Catalyzed Asymmetric Construction of Vicinal Tertiary and All-Carbon Quaternary Stereocenters by Allylation of β-Ketocarbonyls with Morita-Baylis-Hillman Adducts.
- Authors
Liu, Jiawang; Han, Zhaobin; Wang, Xiaoming; Meng, Fanye; Wang, Zheng; Ding, Kuiling
- Abstract
Palladium-catalyzed regio-, diastereo-, and enantioselective allylic alkylation of β-ketocarbonyls with Morita-Baylis-Hillman adducts has been developed using a spiroketal-based diphosphine (SKP) as the ligand, thus affording a range of densely functionalized products bearing vicinal tertiary and all-carbon quaternary stereodyad in high selectivities. The utility of the protocol was demonstrated by the facile synthesis of some complex molecules by simple product transformations.
- Subjects
PALLADIUM; ALLYLATION; ALKYLATION; CHEMICAL adducts; QUATERNARY structure
- Publication
Angewandte Chemie, 2017, Vol 129, Issue 18, p5132
- ISSN
0044-8249
- Publication type
Article
- DOI
10.1002/ange.201701455