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- Title
Nickel-Catalyzed Chemo- and Enantioselective Coupling between Cyclobutanones and Allenes: Rapid Synthesis of [3.2.2] Bicycles.
- Authors
Zhou, Xuan; Dong, Guangbin
- Abstract
Herein an intramolecular nickel-catalyzed (4+2) coupling between cyclobutanones and allenes, by C−C cleavage, is reported. The reaction provides a distinct approach for accessing [3.2.2] bicyclic scaffolds which are challenging to prepare through conventional approaches. The reaction is efficient, chemoselective, and pH/redox neutral. Room temperature conditions and low catalyst loadings can be adopted. Excellent enantioselectivity is also achieved.
- Subjects
CYCLOBUTANONES; ALLENE; BICYCLIC compounds; CHEMOSELECTIVITY; ENANTIOSELECTIVE catalysis
- Publication
Angewandte Chemie, 2016, Vol 128, Issue 48, p15315
- ISSN
0044-8249
- Publication type
Article
- DOI
10.1002/ange.201609489