We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Palladium-Catalyzed Dearomative Cyclocarbonylation by CN Bond Activation.
- Authors
Yu, Hui; Zhang, Guoying; Huang, Hanmin
- Abstract
A fundamentally novel approach to bioactive quinolizinones is based on the palladium-catalyzed intramolecular cyclocarbonylation of allylamines. [Pd(Xantphos)I2], which features a very large bite angle, has been found to facilitate the rapid carbonylation of azaarene-substituted allylamines into bioactive quinolizinones in good to excellent yields. This transformation represents the first dearomative carbonylation and is proposed to proceed by palladium-catalyzed CN bond activation, dearomatization, CO insertion, and a Heck reaction.
- Subjects
ALLYLAMINES; HETEROCYCLIC compounds; PALLADIUM catalysts; CHEMICAL synthesis; CHEMICAL research
- Publication
Angewandte Chemie, 2015, Vol 127, Issue 37, p11062
- ISSN
0044-8249
- Publication type
Article
- DOI
10.1002/ange.201504805