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- Title
Enzymatic synthesis of water-soluble derivatives of salicylic acid in organic media.
- Authors
Maugard, Thierry; Boulonne, Melanie; Rejasse, Barbara; Dominique Legoy, Marie
- Abstract
A novel enzymatic method for preparing water-soluble derivatives of salicylic acid catalyzed by immobilized lipase was described. This study is the first to describe the enzymatic transesterification of methyl salicylate in organic solvents with different hydroxyl donors. The acyl-transfer between methyl salicylate and sorbitol was best supported by solvents of log P values -0.33 to 1.4. With Candida antarctica lipase in tert-amyl alcohol, a sorbitol conversion yield of 98% can be obtained by transesterification with sorbitol and methyl salicylate in one step.
- Subjects
SALICYLIC acid; ORGANIC solvents; ENZYMES; LIPASES; SORBITOL; ALCOHOL
- Publication
Biotechnology Letters, 2001, Vol 23, Issue 12, p989
- ISSN
0141-5492
- Publication type
Article
- DOI
10.1023/A:1010575309233