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- Title
A global systematic evidence review with meta-analysis of the epidemiological characteristics of the 2022 Mpox outbreaks.
- Authors
Okoli, George N.; Van Caeseele, Paul; Askin, Nicole; Abou-Setta, Ahmed M.
- Abstract
Background: In 2022, there were outbreaks of Mpox where the disease is not endemic. We summarized published full-text epidemiological data from the outbreaks. Methods: A global evidence review (protocol: osf.io/j3kb7) with systematic literature search up to February 09, 2023. We focused on experimental/observational studies of laboratory confirmed Mpox, excluding case reports and case series of < 5 cases. Epidemiological data were pooled using an inverse variance, random-effects model, and pooled estimates presented with associated 95% confidence intervals. Results: We included 66 studies. Mean incubation period was 7.8 days (6.6–9.0 days, 8 studies: 560 cases), reproductive number 1.8 (1.7–1.9, 6 studies), mean duration from symptom onset to diagnosis 5.8 days (4.8–6.8 days, 4 studies: 982 cases), mean symptom duration 17.5 days (14.7–20.2 days, 3 studies: 292 cases), mean serial interval 8.5 days (7.3–9.9 days, 1 study), hospitalisation 6% (4–9%, 26 studies: 5339 cases), and vaccine effectiveness 78% (65–91%, 3 studies: 953 cases). Highly relevant clinical manifestations were pleomorphic skin lesions 82% (68–94%, 26 studies: 4093 cases), anogenital lesions 64% (51–77%, 9 studies: 10,398 cases), fever 54% (50–57%, 52 studies: 25,992 cases), and lymphadenopathy 51% (46–57%, 42 studies: 17,803 cases), with cases mostly men who have sex with men (MSM). Possibly relevant manifestations were perianal lesions, fatigue, asthenia, myalgia, and headache. Conclusions: The 2022 Mpox outbreaks presented with sex-related clinical manifestations and were mostly reported among MSM.
- Subjects
DISEASE duration; SYMPTOMS; META-analysis; DESCRIPTIVE statistics; SYSTEMATIC reviews; MEDLINE; MONKEYPOX; CONFIDENCE intervals
- Publication
Infection, 2024, Vol 52, Issue 3, p901
- ISSN
0300-8126
- Publication type
Article
- DOI
10.1007/s15010-023-02133-5