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- Title
Multiplex real-time PCR for prompt diagnosis of an outbreak of human parainfluenza 3 virus in children with acute leukemia.
- Authors
Berrueco, R.; Antón, A.; Rives, S.; Català, A.; Toll, T.; Ruiz, A.; Camós, M.; Torrebadell, M.; Estella, J.; Muñoz-Almagro, C.
- Abstract
Introduction: Human parainfluenza virus type 3 (HPIV-3) causes significant morbimortality in immunocompromised patients. Outbreaks of severe pneumonitis have been previously described in this setting. Materials and methods: Retrospective observational study in children diagnosed with acute leukemia and a documented HPIV-3 infection in the context of a nosocomial outbreak occurred in a single center. Result: During summer 2012, an HPIV-3 infection was detected in six hospitalized children with acute leukemia. All the patients had respiratory symptoms and one of them suffered from parotitis. Conclusion: Early diagnoses using multiplex real-time polymerase chain reaction (PCR) let us control this outbreak. A phylogenetic analysis confirmed person-to-person transmission of a single HPIV-3 variant.
- Subjects
SPAIN; EARLY diagnosis; RNA virus infections; ACADEMIC medical centers; LYMPHOBLASTIC leukemia; MEDICAL records; POLYMERASE chain reaction; RESEARCH funding; RETROSPECTIVE studies; DIAGNOSIS
- Publication
Infection, 2013, Vol 41, Issue 6, p1171
- ISSN
0300-8126
- Publication type
Article
- DOI
10.1007/s15010-013-0498-8