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- Title
Effects of gender, age, and body mass index on fat contents and apparent diffusion coefficients in healthy parotid glands: an MRI evaluation.
- Authors
Chang, Hing-Chiu; Juan, Chun-Jung; Chiu, Hui-Chu; Cheng, Cheng-Chieh; Chiu, Su-Chin; Liu, Yi-Jui; Chung, Hsiao-Wen; Hsu, Hsian-He
- Abstract
Objectives: To establish standard apparent diffusion coefficient (ADC) and the fat content as a function of age, gender and body mass index (BMI) in healthy parotid glands, and to address the influences of fat suppression on ADC measurements. Methods: A total of 100 healthy adults (gender and age evenly distributed) were prospectively recruited, with parotid fat content measured from gradient-echo images with fat-water separated using iterative decomposition with echo asymmetry and least squares (IDEAL). The ADCs were estimated using both fat-saturated and non-fat-saturated diffusion-weighted imaging via a periodically rotated overlapping parallel lines with enhanced reconstruction (PROPELLER) technique. Results: Parotid fat content was larger in men than in women by about 10 percentage points ( P < 0.005), and positively associated with BMI and age for both genders (mostly with P < 0.001). ADCs estimated with non-fat-saturated PROPELLER were significantly lower in men than in women ( P < 0.005), but showed no gender difference if measured using fat-saturated PROPELLER ( P = 0.840). The negative association between parotid ADC and age/BMI/fat ( P < 0.001) showed greater regression slopes in non-fat-saturated PROPELLER than in fat-saturated data. Conclusions: Parotid fat content in healthy adults correlates positively with both age and BMI; the correlation with age is gender-dependent. Parotid ADC measurements are strongly influenced by fat saturation. Key Points: • Parotid fat content in healthy adults correlates positively with age and BMI. • The rate of aging-related increase in fat contents is gender-dependent. • Parotid ADC measurements are strongly influenced by fat saturation.
- Subjects
MAGNETIC resonance imaging; PAROTID glands; BODY mass index; BODY composition; FAT
- Publication
European Radiology, 2014, Vol 24, Issue 9, p2069
- ISSN
0938-7994
- Publication type
Article
- DOI
10.1007/s00330-014-3265-z