We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Prognostic factors of pediatric pineal region tumors at a single institution.
- Authors
Valsechi, Linoel Curado; da Costa, Marcos Devanir Silva; Dastoli, Patrícia Alessandra; Nicácio, Jardel Mendonça; Suzuki, Fernando Seiji; Leite, Adriana Lima; Cavalheiro, Sérgio
- Abstract
Purpose: This study aimed to identify factors of a worse prognosis among different histological types of pineal region tumors in pediatric patients treat at a single institution in a 30-year period. Material and methods: Pediatric patients (151; < 18 years of age) treated between 1991 and 2020 were analyzed. Kaplan-Meyer survival curves were created, and the log-rank test was used to compare the main prognostic factors in the different histological types. Results: Germinoma was found in 33.1%, with an overall 60-month survival rate of 88%; the female sex was the only factor of a worse prognosis. Non-germinomatous germ cell tumors were found in 27.1%, with an overall 60-month survival rate of 67.2%; metastasis upon diagnosis, residual tumor, and the absence of radiotherapy were associated with a worse diagnosis. Pineoblastoma was found in 22.5%, with an overall 60-month survival rate of 40.7%; the male sex was the only factor of a worse prognosis; a tendency toward a worse outcome was found in patients < 3 years of age and those with metastasis upon diagnosis. Glioma was identified in 12.5%, with an overall 60-month survival rate of 72.6%; high-grade gliomas were associated with a worse prognosis. Atypical teratoid rhabdoid tumors was found in 3.3%, and all patients died within a 19-month period. Conclusion: Pineal region tumors are characterized by the heterogeneity of histological types, which exert an influence on the outcome. Knowledge of the prognostic factors for each histological types is of extreme importance to the determination of guided multidisciplinary treatment.
- Subjects
PROGNOSIS; TERATOMA; SURVIVAL rate; LOG-rank test; CHILD patients
- Publication
Child's Nervous System, 2023, Vol 39, Issue 9, p2329
- ISSN
0256-7040
- Publication type
Article
- DOI
10.1007/s00381-023-05952-x