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- Title
Histopathology and electron microscopy of three cases of subacute sclerosing panencephalitis (SSPE).
- Authors
Oyanagi, Shinsaku; Rorke, Lucy; Katz, Michael; Koprowski, Hilary
- Abstract
Brain tissue obtained by biopsy from three patients with subacute sclerosing panencephalitis (SSPE) was examined under the light and the electron microscope. Histologically all the cases showed some degree of abnormality of both the gray and the white matter. Inclusion bodies were found in one case in which changes in the white matter were minimal. In the other two cases, where inclusion bodies were not identified, astrocytic proliferation in the white matter was more conspicuous. In electron microscopy four abnormal findings were observed, but all were not necessarily seen in each case. Two types of nucleocapsid structures, smaller and larger, of the type seen in measles-infected cells, were identified in one case. The smaller nucleocapsids formed either nuclear or cytoplasmic inclusions and the larger ones usually aggregated in the cytoplasm. Nuclear bodies were seen in all the cases. Lattice-like structures and bundles of fibrillar material were also observed in two cases.
- Publication
Acta Neuropathologica, 1971, Vol 18, Issue 1, p58
- ISSN
0001-6322
- Publication type
Article
- DOI
10.1007/BF00684475