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- Title
Analysis of HIV-1 CRF07_BC gag p6 sequences indicating novel deletions in the central region of p6.
- Authors
Song, Y. H.; Meng, Z. F.; Xing, H.; Ruan, Y. H.; Li, X. P.; Xin, R. L.; Ma, P. F.; Peng, H.; Shao, Y.
- Abstract
We amplified gag sequences from 66 individuals infected with HIV-1 CRF07_BC during 2003–2005 in the Xinjiang region of China. A novel deletion of 7aa (including a KELY motif) in the central region of the CRF07_BC gag p6 domain was detected, which has not been reported in other HIV-1 subtypes. Further deletions of up to 13aa (including KQE and KELY motifs) was also found in this domain, representing the biggest natural deletion up to now. Moreover, the CD4+ count and viral load level indicated that 1–13aa deletions in CRF07_BC gag p6 do not have a significant effect on viral replication and fitness.
- Subjects
XINJIANG Uygur Zizhiqu (China); CHINA; HIV; AIDS research; RETROVIRUSES; VIRAL replication
- Publication
Archives of Virology, 2007, Vol 152, Issue 8, p1553
- ISSN
0304-8608
- Publication type
Report
- DOI
10.1007/s00705-007-0973-6