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- Title
4-Hydroxy-2-quinolones. 152*. 3-acetyl-4-hydroxy-2-oxo-1,2-dihydroquinoline and its biologically active derivatives.
- Authors
Ukrainets, I. V.; Tkach, A. A.; Liu Yang Yang
- Abstract
A synthesis and study of the spatial structure of 3-acetyl-4-hydroxy-2-oxo-1,2-dihydroquinoline have been carried. 1-R-4-hydroxy-2-oxo-1,2-dihydroquinoline-3-carboxylic acids [1-(4-hydroxy-2-oxo-1,2-dihydroquinolin-3-yl)ethylidene]hydrazides were prepared from this compound by two routes. A comparative analysis of the antitubercular properties of the synthesized compounds and of the closely structurally related N,N′-di(1-R-4-hydroxy-2-oxo-1,2-dihydroquinoline-3-carbonyl)hydrazines has been performed.
- Subjects
QUINOLONE antibacterial agents; HYDROXY acids; COMPARATIVE studies; HYDRAZINES; ANTITUBERCULAR agents; BIOSYNTHESIS
- Publication
Chemistry of Heterocyclic Compounds, 2009, Vol 45, Issue 2, p169
- ISSN
0009-3122
- Publication type
Article
- DOI
10.1007/s10593-009-0246-2