We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
In-vitro activity of DR-3355, an optically active isomer of ofloxacin, against bacterial pathogens associated with travellers' diarrhoea.
- Authors
Inagaki, Yoshio; Horiuchi, Sankichi; Une, Tsutomu; Nakaya, Rintaro; Inagaki, Y; Horiuchi, S; Une, T; Nakaya, R
- Abstract
The in-vitro activity of DR-3355, the S-(-)-isomer of ofloxacin, was determined against bacterial pathogens associated with travellers' diarrhoea. DR-3355 was highly active against isolates of enteropathogenic Escherichia coli (MIC90 0.05 mg/l), Salmonella spp. (MIC90 0.10 mg/l), Shigella spp. (MIC90 0.10 mg/l), Campylobacter jejuni (MIC90 0.39 mg/l) and Vibrio parahaemolyticus (MIC90 0.39 mg/l). The activity of DR-3355 against these bacteria was generally two- to eight-fold greater than that of ofloxacin and equal to, or only two-fold less than, that of ciprofloxacin with the exception of isolates of C. jejuni, which were two-fold less susceptible to ciprofloxacin than to DR-3355.
- Publication
Journal of Antimicrobial Chemotherapy (JAC), 1989, Vol 24, Issue 4, p547
- ISSN
0305-7453
- Publication type
journal article