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- Title
The prophylactic use of ticarcillin/clavulanate in the neonate.
- Authors
Fayed, S. B.; Sutton, A. M.; Turner, T. L.; McAllister, T. A.
- Abstract
A combination of ticarcillin and clavulanic acid (ratio 15:1) was given prophylactically to 24 newborn infants at risk of infection. Serum and urine concentrations of ticarcillin and clavulanic acid were measured after the first parenteral dose. Fifteen of 22 organisms isolated from the infants were sensitive to the drug. The pharmacokinetic profile was satisfactory and the combination was well tolerated.
- Subjects
BACTERIAL disease prevention; PREMATURE infant disease prevention; PENICILLIN; COMBINATION drug therapy; CLAVULANIC acid; DYNAMICS; ENZYME inhibitors; TICARCILLIN; THERAPEUTICS
- Publication
Journal of Antimicrobial Chemotherapy (JAC), 1987, Vol 19, Issue 1, p113
- ISSN
0305-7453
- Publication type
journal article