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- Title
Design, synthesis and structure-activity relationships of novel ALS inhibitors
- Authors
Cheng, F.-H.; Yang, X.-L.; Gao, X.; Zhou, J.-J.; Yang, H.-W.; Ren, T.-R.
- Abstract
The paper describes the biophore models of sulfonylurea, imidazolinone, triazolopyrimidinesulfonamide and 5-pyrimidyltriazolo-3-sulfonamides established by the Apex-3D method. A series of N-phenylsulfonyl-N' -(thiadiazol-2-yl)oxamides and three types of triazolopyrimidinesulfonamide were synthesised and their herbicidal activities determined to assess the validity of the model. In general, the model gave useful leads to activity, although the actual level was not always predicted accurately. In only a few cases did compounds predicted as being active prove to be inactive in the bioassay, and compounds with littleor no activity were clearly indicated. As a result of this work, thecompound N,N' -[1-(5,7-dimethyl-1,2,4-triazolo[1,5-a]pyrimidin-2 -yl-thio)butane-2,3-di-imino]bis(2-chlorobenzenesu lfonamide) was selected as showing good activity against a range of species, and will be used as a lead for further development.
- Subjects
HERBICIDES; ACETOLACTATE synthase; WEED science
- Publication
Pest Management Science, 2000, Vol 56, Issue 3, p218
- ISSN
1526-498X
- Publication type
Article