We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Transfer of Drug Resistance Characteristics Between Cancer Cell Subpopulations: A Study Using Simple Mathematical Models.
- Authors
Rosa Durán, María; Podolski-Renić, Ana; Álvarez-Arenas, Arturo; Dinić, Jelena; Belmonte-Beitia, Juan; Pešić, Milica; Pérez-García, Víctor
- Abstract
Resistance to chemotherapy is a major cause of cancer treatment failure. The processes of resistance induction and selection of resistant cells (due to the over-expression of the membrane transporter P-glycoprotein, P-gp) are well documented in the literature, and a number of mathematical models have been developed. However, another process of transfer of resistant characteristics is less well known and has received little attention in the mathematical literature. In this paper, we discuss the potential of simple mathematical models to describe the process of resistance transfer, specifically P-gp transfer, in mixtures of resistant and sensitive tumor cell populations. Two different biological hypotheses for P-gp transfer are explored: (1) exchange through physical cell-cell connections and (2) through microvessicles released to the culture medium. Two models are developed which fit very well the observed population growth dynamics. The potential and limitations of these simple 'global' models to describe the aforementioned biological processes involved are discussed on the basis of the results obtained.
- Subjects
DRUG resistance in cancer cells; MATHEMATICAL models; CANCER chemotherapy; CANCER treatment; GENETIC overexpression
- Publication
Bulletin of Mathematical Biology, 2016, Vol 78, Issue 6, p1218
- ISSN
0092-8240
- Publication type
Article
- DOI
10.1007/s11538-016-0182-0