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- Title
Prognostic Implication of Baseline Sarcopenia for Length of Hospital Stay and Survival in Patients With Coronavirus Disease 2019.
- Authors
Kim, Ji-Won; Yoon, Jun Sik; Kim, Eun Jin; Hong, Hyo-Lim; Kwon, Hyun Hee; Jung, Chi Young; Kim, Kyung Chan; Sung, Yu Sub; Park, Sung-Hoon; Kim, Seong-Kyu; Choe, Jung-Yoon
- Abstract
<bold>Background: </bold>The impact of sarcopenia on clinical outcomes of coronavirus disease 2019 (COVID-19) is not clearly determined yet. We aimed to investigate the association between baseline sarcopenia and clinical outcomes in patients with COVID-19.<bold>Methods: </bold>All hospitalized adult patients with COVID-19 who had baseline chest computed tomography (CT) scans at a Korean university hospital from February 2020 to May 2020 were included. The main outcome was time from hospital admission to discharge. Death was considered as a competing risk for discharge. Baseline skeletal muscle cross-sectional area at the level of the 12th thoracic vertebra was measured from chest CT scans. The lowest quartile of skeletal muscle index (skeletal muscle cross-sectional area divided by height-squared) was defined as sarcopenia.<bold>Results: </bold>Of 121 patients (median age, 62 years; 44 men; 29 sarcopenic), 7 patients died and 86 patients were discharged during the 60-day follow-up. Patients with sarcopenia showed a longer time to discharge (median, 55 vs 28 days; p < .001) and a higher incidence of death (17.2% vs 2.2%; p = .004) than those without sarcopenia. Baseline sarcopenia was an independent predictor of delayed hospital discharge (adjusted hazard ratio [aHR], 0.47; 95% confidence interval [95% CI], 0.23-0.96), but was not independently associated with mortality in patients with COVID-19 (aHR, 3.80; 95% CI, 0.48-30.26). The association between baseline sarcopenia and delayed hospital discharge was consistent in subgroups stratified by age, sex, comorbidities, and severity of COVID-19.<bold>Conclusions: </bold>Baseline sarcopenia was independently associated with a prolonged hospital stay in patients with COVID-19. Sarcopenia could be a prognostic marker in COVID-19.
- Subjects
COVID-19; LENGTH of stay in hospitals; SARCOPENIA; HOSPITAL admission &; discharge; PROGNOSIS
- Publication
Journals of Gerontology Series A: Biological Sciences & Medical Sciences, 2021, Vol 76, Issue 8, pe110
- ISSN
1079-5006
- Publication type
journal article
- DOI
10.1093/gerona/glab085