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- Title
The prevalence of selective IgA deficiency in type 1 diabetes mellitus.
- Authors
LIBLAU, ROLAND S.; CAILLAT-ZUCMAN, SOPHIE; FISCHER, ANNE-MARIE; BACH, JEAN-FRANCOIS; BOITARD, CHRISTIAN
- Abstract
A significant increase in the prevalence of selective IgA deficiency has been observed in patients with autoimmune disorders such as systemic lupus erythematosus and rheumatoid arthritis. Insulin-dependent diabetes mellitus (IDDM) is an autoimmune disease and susceptibility to both IDDM and IgA deficiency is associated with HLA DQB1 alleles encoding non-Asp amino acids at position 57. In order to assess whether the prevalence of selective IgA deficiency is increased in IDDM, we have screened a homogeneous series of adult patients with IDDM for selective IgA deficiency. One patient (1:261) was found to have a selective IgA deficiency. The prevalence of selective IgA deficiency among adult French blood donors is 1:1400. Thus, although IDDM and selective IgA deficiency are both associated with the presence of non-Asp amino acids at position 57 of the HLA DQβ chain, the frequency of this immunodeficiency in adult IDDM patients is not significantly increased.
- Publication
APMIS, 1992, Vol 100, Issue 7-12, p709
- ISSN
0903-4641
- Publication type
Article
- DOI
10.1111/j.1699-0463.1992.tb03988.x