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- Title
呼气末二氧化碳分压在评估心脏骤停大鼠模型复苏结果中的作用.
- Authors
郭建; 王世伟; 陆晓晔; 杨正飞; 凌钦; 杨倩; 朱长清
- Abstract
Objective: To explore the difference between ventricular and asphyxial cardiac arrest animal model in the pressure of end tidal carbon dioxide(PETCO2) and evaluate its potential role in predicting the resuscitation outcome. Methods: Cardiac arrest-resuscitation SD rat model was established by ventricular and asphyxial method respectively. Continuous measurements of PETCO2 was performed at different resuscitation time points, including precordial compression 0 min(PC0 min), PC1 min, PC2 min, PC3 min, PC4 min, PC5 min and PC6 min in the two groups. The difference of PETCO2 was analyzed between the two groups as well as the ROSC rats and NOROSC rats within the individual group. In addition, a PETCO2 receiver operating characteristic curve(ROC curve) was also described in the two groups. Results: 9 out of 12 were successfully resuscitated in asphyxial group vs 8/12 in ventricular group,(P =0.093). The average resuscitated time differs from 232±20 S in asphyxial group to 360±30 s in ventricular group(P<0.001). PETCO2 declined dramatically in ventricular group compared with baseline(P<0.001)while in asphyxial group the PETCO2 first rises then falls.From PC0 45 ±4 vs 36 ±4 mm Hg to PC3, PETCO2 levels in asphyxial was much higher than that of ventricular group(P <0.001).Comparison within the group found that levels of PETCO2 in ROSC rats were higher than those of NOROSC in ventricular group at PC5&PC6 with a AUC(Area Under Curve) 0.713 [95%CI(0.512, 0.764)] and 0.875[95%CI(0.662, 0.984)] respectively. When 20 mm Hg was selected as a threshhold according to Youden index, the sensitivity and specificity was 66.6% and 63% in PC5. In PC6 the threshhold was 18 mm Hg with a sensitivity and specificity 87.4% and 71%. PETCO2 seems lower in NOROSC rats compared with ROSC ones in asphyxial group, but no difference was observed. Conclusion: PETCO2 may help to distinguish the cause of cardiac arrest in early resuscitation from ventricular or asphyxial. The level of PETCO2 may help to evaluate the resuscitation outcome in ventricular induced cardiac arrest.
- Publication
Progress in Modern Biomedicine, 2019, Vol 19, Issue 10, p1818
- ISSN
1673-6273
- Publication type
Article
- DOI
10.13241/j.cnki.pmb.2019.10.004