We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
磁共振灌注加权成像与弥散加权成像在脑胶质瘤分级诊断中的应用.
- Authors
王大堃; 任静; 刘辉; 陈琛; 王江峰; 董涛
- Abstract
Objective: To explore the value of perfusion weighted imaging and diffusion weighted imaging in grading diagnosis of glioma. Methods: Selected 100 glioma patients in our hospital from January 2012 to June 2017. Pathologically confirmed high and low grade glioma patients each have 44, 56 cases. All patients underwent PWI, DWI examination. ADC and rCBF of different regions of glioma were compared. The rADC and rrCBF of different grades of tumor parenchyma and peritumoral edema of glioma patients were compared. According to ROC curve, the diagnostic threshold, sensitivity and specificity of rADC and rrCBF in different grades of gliomas were analyzed. Results: Compared with corresponding normal brain parenchyma, ADC and rCBF in peritumoral edema and tumor parenchyma were significantly increased (P<0.05). Compared with the peritumoral edema area, ADC and rCBF in the parenchyma of the tumor were significantly increased (P<0.05). The rADC of the high grade tumor was significantly lower than that of the low grade tumor (P<0.05) and rrCBF was significantly higher than that of the tumor (P <0.05). There was no significant difference between high-grade peritumoral edema and low-grade peritumoral edema rADC (P>0.05). The rrCBF in high-grade peritumoral edema was significantly higher than that in low-grade peritumoral edema (P<0.05). According to ROC curve analysis, the area under the curve of rADC and rrCBF under the classification of high and low grade gliomas were 0.957, 0.978. The sensitivity, specificity and threshold value of rADC in diagnosing different grade glioma were 90.12 %, 95.26 % and 13.12, respectively. The sensitivity, specificity and threshold value of rrCBF in diagnosing different grade glioma were 92.31 %, 98.57 % and 2.62 respectively. There was no significant difference between rADC and rrCBF in diagnosis of gliomas with different grading (P<0.05). Conclusions: PWI, DWI can provide a reference for the grading diagnosis of gliomas.
- Subjects
GLIOMA treatment; MAGNETIC resonance angiography; DIAGNOSIS of edema; HOSPITALS; CEREBRAL circulation
- Publication
Progress in Modern Biomedicine, 2018, Vol 18, Issue 16, p3115
- ISSN
1673-6273
- Publication type
Article
- DOI
10.13241/j.cnki.pmb.2018.16.025