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- Title
降香通过抗氧化应激改善后负荷增加型心衰小鼠的心脏功能.
- Authors
赵美娜; 肖凡; 李国华; 吴洁; 李嘉; 卫培峰; 奚苗苗
- Abstract
Objective: To explore the protective effect of Dalbergiae Odoriferae (DO) on cardiac dysfunction in pressure overload-induced failing heart in mice and the underlying mechanisms. Methods: C57 mice (male. 6 weeks) were used for induction of HF through pressure overload. Pressure overload was produced by transverse aortic constriction (TAC) as described previously. After surgery, the mice were randomized to given vehicle or DO for 4 weeks. An in vitro study was performed on cultured cardiomyocytes subjected to control, H2O2,H2O2+DO and H2O2+DO.H2O2+TEMPOL. Results: Cardiac ejection fraction (EF) was decreased and myocardial remodeling was significant in response to pressure overload, along with cardiac TOAC level was dropped and maloudialdehyde (MDA) production were significantly elevated, which led to dampened cardiac function and myocardial remodeling. DO treatment significantly reduced MDA production and improved cardiac dysfunction. Importantly, incubation of cardiomyocytes with HJD; significantly induced cell death. Treatment with DO or ROS Scavenger TEMPOL reduced oxidative stress induced by H2O2; and increased cell viability. Conclusions: DO treatment alleviates oxidative stress in the progress of heart failure, which improves cardiac dysfunction and normalized myocardial remodeling.
- Publication
Progress in Modern Biomedicine, 2018, Vol 18, Issue 10, p1842
- ISSN
1673-6273
- Publication type
Article
- DOI
10.13241/j.cnki.pmb.2018.10.008