We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
E-cadherin 在宫颈上皮内瘤变及宫颈癌中的表达及其 与高危型HPV感染的相关性.
- Authors
李玲; 马燕玲; 马华玲; 张文娟; 郑明军
- Abstract
Objective: To study the expession of E-cadherin, high risk human papillomavirus (HR-HPV) in cervical cancer and pre-malignant lesion, and discuss the role of them in occurrence and development of cervical cancer. Methods: From January 2008 to December 2014, 150 cases of cervical cance and pre-malignant lesion were collected. Cervical tissues were divided into CIN grade I group, CIN grade II -III group and cervical cancer group. The expressions of E-cadherin were detected by immunohistochemical method, the high-risk HPV infection in the patients were detected by PCR-reverse dot blot hybridization method, and the statistical analysis was performed. Results: (1) The positive expression of E-cadherin in groups were respectively 80.0 %, 48.0 %, 34.0 %. There were significant differences in CIN grade I, CIN II-III and cervical cancer groups (P<0.05); The expression of E-cadherin was significantly decreased with the progression of disease, and there were significant differences between the groups (P<0.05). (2) Positive infection rate of HR-HPV in CIN grade I, CIN II-III and cervical cancer groups were 42.0 %, 76.0 %, 96.0 %. There were significant differences between the groups (P<0.05). (3) In CIN and cervical cancer, the positive rate of E-cadherin in HR-HPV positive group was 39.3% (42/107) lower than that in HR-HPV negative group was 90.7%(39/43) (P<0.05); In CIN and cervical cancer, The expression of E-cadherin was negatively correlated with high risk type HPV infection. Conclusiona: The decrease or loss of E-cadherin expression may be one of the mechanisms of HR-HPV in the genesis and development of cervical cancer.
- Publication
Progress in Modern Biomedicine, 2017, Vol 17, Issue 6, p1090
- ISSN
1673-6273
- Publication type
Article
- DOI
10.13241/j.cnki.pmb.2017.06.023