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- Title
替莫唑胺治疗垂体瘤患者的临床疗效及机制研究.
- Authors
杨瑞林; 杨永青; 李博; 第五飞虎; 刘强; 肖西峰
- Abstract
Objective: To investigate the effects of serum prolactin, IGF-1 and clinical efficacy by temozolomide in patients with hypophysoma. Methods: A total of 70 patients with hypophysoma fromour hospital were collected and randomly divided into experiment group and control group with 35 cases in each group. Patients in the control group were treated by paranasal sinus surgical treatment with microscope, and bromocriptine 1.25 mg/time oral, 3 times/day, patients in the experiment group were treated on the base of the control group with temozolomide. After treatment, compared the serum prolactin, IGF-1 and GH levels between the two groups before and after treatment. Results: Compared with before treatment, the PRL, IGF-1 and GH levels were decreased after treatment (P<0.05), TSH was decreased, FT4 and ACTH were increased, the difference was statistical significance (P<0.05); compared with the control group, the total effective rate of the experiment group was higher, the PRL and IGF-1 levels were lower (P<0.05), TSH level was lower, FT4 and ACTH levels were higher, the difference was statistical significance (P<0.05). Conclusions: Temozolomide in the treatment of hypophysoma has a good clinical effect, speculate that the mechanismis relate to the decrease of serumprolactin and IGF-1 levels.
- Publication
Progress in Modern Biomedicine, 2016, Vol 16, Issue 29, p5749
- ISSN
1673-6273
- Publication type
Article
- DOI
10.13241/j.cnki.pmb.2016.29.041