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- Title
Improving the efficiency of molecular replacement by utilizing a new iterative transform phasing algorithm.
- Authors
He, Hongxing; Fang, Hengrui; Miller, Mitchell D.; Phillips, George N.; Su, Wu-Pei
- Abstract
An iterative transform method proposed previously for direct phasing of high-solvent-content protein crystals is employed for enhancing the molecular-replacement (MR) algorithm in protein crystallography. Target structures that are resistant to conventional MR due to insufficient similarity between the template and target structures might be tractable with this modified phasing method. Trial calculations involving three different structures are described to test and illustrate the methodology. The relationship of the approach to PHENIX Phaser-MR and MR-Rosetta is discussed.
- Subjects
ITERATIVE methods (Mathematics); PROTEIN crystallography; AB initio quantum chemistry methods
- Publication
Acta Crystallographica. Section A, Foundations & Advances, 2016, Vol 72, Issue 5, p539
- ISSN
2053-2733
- Publication type
Article
- DOI
10.1107/S2053273316010731