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- Title
Synthesis, Type II Diabetes Inhibitory Activity, and Antimicrobial Tests of Benzothiazole Derivatives Bridged with Indenedione by Methylenehydrazone.
- Authors
Mor, S.; Sindhu, S.; Khatri, M.; Singh, N.; Vasudeva, N.; Panihar, N.
- Abstract
Benzothiazolyl hydrazones are synthesized and tested as hypoglycemic and antimicrobial agents. Condensation of 2-acyl-(1H)-indene-1,3(2H)-diones with 2-hydrazinylbenzo[d]thiazole/2-hydrazinyl-6-substitutedbenzo[d]thiazoles gives the corresponding hydrazones in high yields. Preliminary biological assay of the products reveals significant antidiabetic and antimicrobial activities. The α-amylase and α-glucosidase inhibition assay is used for determination of Type II diabetes inhibitory activity.
- Subjects
TYPE 2 diabetes; BENZOTHIAZOLE derivatives; BENZOXAZOLES; BIOLOGICAL assay; BIOLOGICAL products; HYPOGLYCEMIC agents
- Publication
Russian Journal of General Chemistry, 2019, Vol 89, Issue 9, p1867
- ISSN
1070-3632
- Publication type
Article
- DOI
10.1134/S1070363219090226