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- Title
Intellectual development in preschool children with early treated congenital hypothyroidism.
- Authors
Min Kyoung Seo; Jong Seo Yoon; Chul Hwan So; Hae Sang Lee; Jin Soon Hwang
- Abstract
Purpose: Delayed treatment of congenital hypothyroidism (CH) is a common cause of mental retardation. The aim of the present study was to evaluate intellectual outcomes in preschool children with treated CH. Methods: We retrospectively reviewed the clinical records of 43 children (age range: 13 to 60 days of life; 22 girls and 21 boys) diagnosed with CH. Children aged 5 to 7 years were examined using the Korean Wechsler Intelligence Scale for Children or the Korean Wechsler Preschool and Primary Scale of Intelligence. Results: The patients started treatment between 13 and 60 days of age. The mean intelligence quotient (IQ) of patients tested at age 5 to 7 years was 103.14±11.68 (IQ range: 76-126). None had intellectual disability (defined as an IQ <70). Twenty-one subjects were treated with a low dose (6.0-9.9 µg/kg/day) and 22 with a high dose of levothyroxine (10.0-16.0 µg/kg/day). There was no significant difference in the mean full-scale IQ (FSIQ), verbal IQ (VIQ), and performance IQ (PIQ) scores between the 2 groups. FSIQ, PIQ, and VIQ scores were not significantly correlated with initial dose of L-T4, initial fT4, age at treatment in multivariate analysis. Conclusion: IQ scores of subjects with early treated CH diagnosed through a neonatal screening test were within normal range, regardless of etiology, thyroid function, initial dose of levothyroxine, and age at start of treatment.
- Subjects
INTELLECTUAL development; DISEASES; PRESCHOOL children; CONGENITAL hypothyroidism; INTELLECTUAL disabilities; INTELLIGENCE levels; LEVOTHYROXINE; THYROID gland function tests; THERAPEUTICS
- Publication
Annals of Pediatric Endocrinology & Metabolism, 2017, Vol 22, Issue 2, p102
- ISSN
2287-1012
- Publication type
Article
- DOI
10.6065/apem.2017.22.2.102