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- Title
Cerebrospinal Fluid from Alzheimer's Disease Patients Promotes Amyloid β-Protein Oligomerization.
- Authors
Ikeda, Tokuhei; Ono, Kenjiro; Elashoff, David; Condron, Margaret M.; Noguchi-Shinohara, Moeko; Yoshita, Mitsuhiro; Teplow, David B.; Yamada, Masahito
- Abstract
Oligomers of the amyloid β-protein (Aβ) play an important role in Alzheimer's disease (AD). We hypothesized that AD patients have a central nervous system environment that promotes Aβ oligomerization. We investigated the effect of cerebrospinal fluid (CSF) from 33 patients with AD and 33 age-matched, non-demented controls on oligomerization of Aβ1-40 and Aβ1-42 using the technique of photo-induced cross-linking of unmodified proteins. CSF inhibited oligomerization of both Aβ1-40 and Aβ1-42. This inhibitory effect was significantly weaker in AD patients than in non-demented controls. Our results indicate that AD patients have a CSF environment favorable for Aβ oligomerization.
- Subjects
OLIGOMERS; ALZHEIMER'S disease; CENTRAL nervous system; CROSSLINKING (Polymerization); PROTEIN analysis
- Publication
Journal of Alzheimer's Disease, 2010, Vol 21, Issue 1, p81
- ISSN
1387-2877
- Publication type
Article
- DOI
10.3233/JAD-2010-100075