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- Title
Cell Ferroptosis: New Mechanism and New Hope for Retinitis Pigmentosa.
- Authors
Yang, Ming; So, Kwok-Fai; Lam, Wai-Ching; Lo, Amy Cheuk Yin
- Abstract
Retinitis pigmentosa (RP) is a leading cause of inherited retinal degeneration, with more than 60 gene mutations. Despite the genetic heterogenicity, photoreceptor cell damage remains the hallmark of RP pathology. As a result, RP patients usually suffer from reduced night vision, loss of peripheral vision, decreased visual acuity, and impaired color perception. Although photoreceptor cell death is the primary outcome of RP, the underlying mechanisms are not completely elucidated. Ferroptosis is a novel programmed cell death, with characteristic iron overload and lipid peroxidation. Recent studies, using in vitro and in vivo RP models, discovered the involvement of ferroptosis-associated cell death, suggesting a possible new mechanism for RP pathogenesis. In this review, we discuss the association between ferroptosis and photoreceptor cell damage, and its implication in the pathogenesis of RP. We propose that ferroptotic cell death not only opens up a new research area in RP, but may also serve as a novel therapeutic target for RP.
- Subjects
RETINITIS pigmentosa; PERIPHERAL vision; APOPTOSIS; PHOTORECEPTORS; NIGHT vision; IRON overload; VISION disorders
- Publication
Cells (2073-4409), 2021, Vol 10, Issue 8, p2153
- ISSN
2073-4409
- Publication type
Article
- DOI
10.3390/cells10082153