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- Title
Elevated fasting plasma C-peptide occurs in non-diabetic individuals with fatty liver, irrespective of insulin resistance.
- Authors
Perseghin, G.; Caumo, A.; Lattuada, G.; De Cobelli, F.; Ntali, G.; Esposito, A.; Belloni, E.; Canu, T.; Ragogna, F.; Scifo, P.; Del Maschio, A.; Luzi, L.
- Abstract
Aims Studies have pointed to insulin resistance as a pathogenic factor in fatty liver. Although pancreatic B-cell function is believed to be involved, its role is unclear. This study was undertaken to test whether fasting C-peptide, an index of fasting B-cell function, was related to intra-hepatic fat (IHF) content in non-diabetic humans. Methods We assessed, retrospectively, fasting plasma C-peptide concentration in 31 patients with fatty liver and 62 individuals without fatty liver. The IHF content was measured by proton magnetic resonance spectroscopy (1H-MRS), while insulin sensitivity was estimated based on fasting plasma glucose and insulin with the homestasis model assessment (HOMA) 2 method. Results Age, sex and body mass index (BMI) were not different between groups. Patients with fatty liver had higher fasting insulin ( P < 0.01), C-peptide ( P < 0.005) and lower insulin sensitivity (HOMA2-%S). Fasting insulin alone explained 14% of the IHF content variability ( P < 0.001); inclusion of fasting C-peptide in multivariate regression explained up to 32% ( P < 0.001). A subgroup analysis was performed by matching 1 : 1 for HOMA2-%S. These data were analysed by conditional logistic regression which showed that, when HOMA2-%S was matched between groups, fasting C-peptide remained the only significant predictor of fatty liver. Conclusions Non-diabetic individuals with fatty liver are characterized by increased fasting plasma C-peptide concentration, irrespective of their insulin resistant state.
- Subjects
C-peptide; FATTY liver; INSULIN resistance; BODY mass index; PROTON magnetic resonance spectroscopy; LOGISTIC regression analysis; MULTIVARIATE analysis
- Publication
Diabetic Medicine, 2009, Vol 26, Issue 9, p847
- ISSN
0742-3071
- Publication type
Article
- DOI
10.1111/j.1464-5491.2009.02785.x