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- Title
Case Report: Immune reconstitution inflammatory syndrome after hematopoietic stem cell transplantation for severe combined immunodeficiency.
- Authors
Shuangjun Liu; Feng Huo; Guorui Dai; Jie Wu; Maoquan Qin; Huawei Mao; Quan Wang
- Abstract
We report a case of immune reconstitution inflammatory syndrome (IRIS) after hematopoietic stem cell transplantation (HSCT). The patient had sever bacillus Calmette–Guerin (BCG) vaccine–caused disseminated infection and had received allogeneic HSCT for X-linked severe combined immunodeficiency disease. After HSCT, complicated by treatment-responding veno-occlusive disease and acute graft-versus-host disease, at the time when immunosuppressants were withdrawn, the patient experienced recurrent fever accompanied by elevated inflammatory indicators. After receiving glucocorticoids and ibuprofen, the patient’s condition improved, and a diagnosis with BCG-related IRIS was made.
- Subjects
SEVERE combined immunodeficiency; HEMATOPOIETIC stem cell transplantation; IMMUNE reconstitution inflammatory syndrome; GRAFT versus host disease; STEM cell transplantation
- Publication
Frontiers in Immunology, 2022, Vol 13, p1
- ISSN
1664-3224
- Publication type
Article
- DOI
10.3389/fimmu.2022.960749