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- Title
Editorial: Multiple Implications of the Kynurenine Pathway in Inflammatory Diseases: Diagnostic and Therapeutic Applications.
- Authors
Mándi, Yvette; Stone, Trevor W.; Guillemin, Gilles J.; Vécsei, László; Williams, Richard O.
- Abstract
Tryptophan (TRP) and kynurenine (KYN), and to a lesser degree 3-hydrox kynurenine (3-HK) are actively transported into the brain over LAT1 transporters. Downstream metabolites of the kynurenine pathway (KP), like quinolinic acid (QUINO) and kynurenic acid (KA), cannot make use of these transporters, but (probably limited) passive diffusion of these metabolites over the BBB is possible. Keywords: kynurenine; IDO; inflammation; neurological disease; inflammatory diseases; AhR EN kynurenine IDO inflammation neurological disease inflammatory diseases AhR 1 3 3 02/14/22 20220211 NES 220211 The kynurenine pathway is responsible for metabolising most of the free tryptophan in mammals.
- Subjects
KYNURENINE; QUINOLINIC acid; AMINOBENZOIC acids
- Publication
Frontiers in Immunology, 2022, Vol 13, p1
- ISSN
1664-3224
- Publication type
Editorial
- DOI
10.3389/fimmu.2022.860867