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- Title
Circulating levels of soluble receptor for advanced glycation end product are inversely associated with vascular calcification in patients on haemodialysis independent of S100 A12 ( EN-RAGE) levels.
- Authors
Kim, Hyung Soo; Chung, Wookyung; Kim, Ae Jin; Ro, Han; Chang, Jae Hyun; Lee, Hyun Hee; Jung, Ji Yong
- Abstract
Aim The receptor for advanced glycation end products ( RAGE) has emerged as a central regulator of vascular inflammation and atherosclerosis. Soluble RAGE ( sRAGE) has an anti-inflammatory effect by quenching ligands for RAGE. On the other hand, extracellular RAGE-binding protein S100 A12 ( EN-RAGE) shows a pro-inflammatory effect in a way, but may play pleiotropic roles related to inflammatory process. Therefore, we determined the levels of sRAGE and S100 A12 in haemodialysis ( HD) patients and evaluated their relationship with vascular calcification. Methods We performed a cross-sectional study with 199 HD patients. Plain X-ray images of the lateral lumbar spine from all subjects were studied to calculate semiquantitative vascular calcification scores ( VCS), as described by Kauppila. Commercially available enzyme linked immunosorbent assay ( ELISA) kits were used to quantify the serum concentration of sRAGE and S100 A12. Results The patients were 57.1 ± 13.7 years of age; 54.3% were male, 49.2% were diabetic, and 36.2% had a history of cardiovascular disease. In a univariate analysis, serum sRAGE was negatively associated with VCS (log sRAGE, r = -0.208, P = 0.003), whereas S100 A12 showed a positive tendency (log S100 A12, r = 0.235, P = 0.085). Even after adjustments for confounding risk factors, sRAGE was independently associated with VCS (β = -1.679, P = 0.002). Conclusion This study demonstrated that the circulating sRAGE level was inversely associated with VCS in HD patients independent of the S100 A12 level and the severity of systemic inflammation.
- Subjects
BLOOD filtration; BLOOD plasma; CARDIOVASCULAR diseases; HEMODIALYSIS; ENZYME-linked immunosorbent assay; UNIVARIATE analysis; CARRIER proteins
- Publication
Nephrology, 2013, Vol 18, Issue 12, p777
- ISSN
1320-5358
- Publication type
Article
- DOI
10.1111/nep.12166