We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Risk factors and outcomes of culture‐proven acute Coccidioides spp. infection in San Diego, California, United States.
- Authors
Jenks, Jeffrey D.; Reed, Sharon L.; Hoenigl, Martin
- Abstract
Summary: Background: Coccidioides spp. are dimorphic fungi endemic to parts of the United States, Mexico, Central and South America. Infection can cause a range of disease from self‐limited acute pneumonia to severe disseminated disease. Methods: We performed a retrospective chart review of medical records of cases of culture‐proven acute coccidioidomycosis at the University of California San Diego between 1 April 2015 and 31 December 2019 and described the demographics, risk factors and outcomes of these cases. Results: Over the study period, fifteen evaluable cases of culture‐proven acute coccidioidomycosis were identified. Of these, 87% (13/15) had traditional risk factors for coccidioidomycosis infection while two lacked known risk factors, including one patient with cirrhosis and one with chronic hepatitis C infection. Seven of fifteen (47%) had primary coccidioidomycosis of the lungs without dissemination and 7/15 (47%) disseminated disease. Of those with disseminated disease, 6/7 (86%) had either high‐risk ethnicity or blood type as their only risk factor. At 90 days, 11/15 (73%) were alive, 3/15 (20%) deceased and 1/15 (7%) lost to follow‐up. Of those not alive at 90 days, 1/3 (33%) had disseminated disease and 2/3 (67%) primary coccidioidomycosis, both on immunosuppressive therapy. Discussion: Coccidioides spp. infection occurs in a variety of hosts with varying underlying risk factors, with the majority in our cohort overall and 86% with disseminated disease lacking traditional risk factors for invasive fungal infection other than ethnicity and/or blood phenotype. Clinicians should be aware of these non‐traditional risk factors in patients with coccidioidomycosis infection.
- Subjects
SAN Diego (Calif.); COCCIDIOIDOMYCOSIS; CHRONIC hepatitis C; MYCOSES; BLOOD groups; INFECTION
- Publication
Mycoses, 2020, Vol 63, Issue 6, p553
- ISSN
0933-7407
- Publication type
Article
- DOI
10.1111/myc.13074