We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Pharmacokinetics of florfenicol and its metabolite, florfenicol amine, in the Korean catfish ( Silurus asotus).
- Authors
Park, B.-K.; Lim, J.-H.; Kim, M.-S.; Yun, H.-I.
- Abstract
The pharmacokinetics of florfenicol and its metabolite, florfenicol amine, was investigated after its intravenous (i.v.) and oral (p.o.) administration of 20 mg/kg of body weight in Korean catfish ( Silurus asotus). After i.v. florfenicol injection (as a bolus), the terminal half-life ( t1/2), the volume of distribution at steady state ( Vdss), and total body clearance were 11.12 ± 1.06 h, 1.09 ± 0.09 L/kg and 0.07 ± 0.01 L·kg/h respectively. After p.o. administration of florfenicol, the t1/2, Cmax, tmax and oral bioavailability ( F) were 15.69 ± 2.59 h, 9.59 ± 0.36 μg/mL, 8 h and 92.61 ± 10.1% respectively. Florfenicol amine, an active metabolite of florfenicol, was detected in all fish. After i.v. and p.o. administration of florfenicol, the observed Cmax values of florfenicol amine (3.91 ± 0.69 and 3.57 ± 0.65 mg/L) were reached at 0.5 and 7.33 ± 1.15 h. The mean metabolic rate of florfenicol amine after i.v. and p.o. administration was 0.4 and 0.5 respectively.
- Subjects
PHARMACOKINETICS; ANTIBACTERIAL agents; SILURUS; DRUG metabolism; DRUG administration; INTRAVENOUS injections; PHARMACODYNAMICS; CATFISHES; ANAEROBIC infections; FISH farming
- Publication
Journal of Veterinary Pharmacology & Therapeutics, 2006, Vol 29, Issue 1, p37
- ISSN
0140-7783
- Publication type
Article
- DOI
10.1111/j.1365-2885.2006.00709.x