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- Title
The effects of oats on the function of gut microflora in children with coeliac disease.
- Authors
Tjellström, B.; Stenhammar, L.; Sundqvist, T.; Fälth‐Magnusson, K.; Hollén, E.; Magnusson, K.‐E.; Norin, E.; Midtvedt, T.; Högberg, L.
- Abstract
Background Faecal short chain fatty acids ( SCFAs) are produced by the gut microflora. We have previously reported high faecal SCFA levels in children with coeliac disease ( CD), indicating alteration in gut microfloral metabolism. Data accumulated over recent decades by us and others suggest that wheat-free oats can safely be included in a gluten-free diet ( GFD). However, concerns have been raised with respect to the safety of oats in a subset of coeliacs. Aim To describe faecal SCFA patterns in children with newly diagnosed CD treated for 1 year with a GFD with or without oats. Methods This report is part of a randomised, double-blind study on the effect of a GFD containing oats ( GFD-oats) vs. a standard GFD ( GFD-std). Faecal samples were received from 34 children in the GFD-oats group and 37 in the GFD-std group at initial diagnosis and/or after 1 year on a GFD. Faecal SCFAs were analysed. Results The GFD-std group had a significantly lower total faecal SCFA concentration at 12 months compared with 0 months ( P < 0.05). In contrast, total SCFA in the GFD-oats group remained high after 1 year on the GFD. The children in the GFD-oats group had significantly higher acetic acid ( P < 0.05), n-butyric acid ( P < 0.05) and total SCFA concentration ( P < 0.01) after 1-year diet treatment compared to the GFD-std group. Conclusions Our results indicate that oats do affect the gut microflora function, and that some coeliac children receiving oats may develop gut mucosal inflammation, that may present a risk for future complications.
- Subjects
FATTY acids; CELIAC disease in children; OATS; GLUTEN-free diet; METABOLISM
- Publication
Alimentary Pharmacology & Therapeutics, 2014, Vol 39, Issue 10, p1156
- ISSN
0269-2813
- Publication type
Article
- DOI
10.1111/apt.12707