We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Comparisons of the distribution of oesophageal acid exposure throughout the sleep period among the different gastro-oesophageal reflux disease groups.
- Authors
DICKMAN, R.; PARTHASARATHY, S.; MALAGON, I. B.; JONES, P.; HAN, B.; POWERS, J.; FASS, R.
- Abstract
Background Nocturnal gastro-oesophageal reflux diseases (GERD) can lead to oesophageal mucosal injury and extra-oesophageal complications. Aim To compare distribution of oesophageal acid exposure during sleep time among patients with non-erosive reflux disease and abnormal pH test (NERD-positive), erosive oesophagitis (EO) and Barrett’s oesophagus (BO). Methods Patients underwent endoscopy followed by 24-h oesophageal pH testing. Oesophageal acid exposure was assessed every 2 h of the sleep period (0–2, 2–4, 4–6 and 6–8 h). Each period of 2 h was evaluated for acid reflux parameters. All groups were matched by age, time from last meal and duration of sleep time. Results Thirty-eight patients were enrolled (NERD-positive, 16; EO, 1.4; and BO, 8). All GERD groups demonstrated higher oesophageal acid exposure in the first vs. second half of the sleep period as determined by percent time pH <4 (BO: 34.7 vs.11.6, EO: 13.5 vs. 6.9, NERD-positive: 8.8 vs. 2.5, all P < 0.01). In general, patients with BO had a significantly higher distribution of oesophageal acid exposure than those with NERD-positive and EO. Conclusions Oesophageal acid exposure generally declines throughout the sleep period regardless of GERD group, but BO patients demonstrated the greatest decline during the sleep period.
- Subjects
GASTROESOPHAGEAL reflux; SLEEP; PATIENTS; ENDOSCOPY; DISEASE complications; ESOPHAGUS
- Publication
Alimentary Pharmacology & Therapeutics, 2007, Vol 26, Issue 1, p41
- ISSN
0269-2813
- Publication type
Article
- DOI
10.1111/j.1365-2036.2007.03347.x