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- Title
The relationships between bone mineral density and radiographic features of hand or knee osteoarthritis in older adults: data from the Dong-gu Study.
- Authors
Lihui Wen; Min-Ho Shin; Ji-Hyoun Kang; Yi-Rang Yim; Ji-Eun Kim; Jeong-Won Lee; Kyung-Eun Lee; Dong-Jin Park; Tae-Jong Kim; Yong-Wook Park; Sun-Seog Kweon; Young-Hoon Lee; Yong-Woon Yun; Shin-Seok Lee
- Abstract
Objective. The relationship between OA and osteoporosis has exhibited contradictory features over the past four decades. The aim of this study was to determine using separate analysis of the radiographic features of OA whether various radiographic features of OA were associated differently with BMD in the Korean elderly. Methods. Data were derived from the Dong-gu cohort; 2354 subjects were enrolled in the present crosssectional study. Baseline characteristics, the BMDs of the lumbar spine and femoral neck measured by DXA, and X-rays of knees and hands were collected. A semi-quantitative grading system was used to estimate the severities of individual radiographic features. We adjusted for confounders using multiple linear regression modelling to analyse the relationships. Results. After adjustment for confounders, hand and knee OA total scores were negatively associated with the BMDs of the lumbar spine and femoral neck, except for the total knee OA score and lumbar spine BMD. In detail, hand osteophytes and sclerosis exhibited positive relationships with the BMDs of the lumbar spine and femoral neck, except for hand osteophytes and femoral neck BMD. On the contrary, however, knee joint space narrowing (JSN), hand JSN, and hand subchondral cysts were negatively associated with the BMD of the lumbar spine and femoral neck. Knee JSN and hand subchondral cysts exerted the greatest effects on BMD. Conclusion. Separate analysis of the radiographic features of OA better reveals associations of OA with the BMD of the lumbar spine and femoral neck.
- Subjects
SOUTH Korea; HAND radiography; SPINE radiography; AGING; CHI-squared test; CONFIDENCE intervals; FEMUR neck; IMMUNOASSAY; KNEE diseases; LONGITUDINAL method; OSTEOARTHRITIS; QUESTIONNAIRES; RESEARCH evaluation; RESEARCH funding; T-test (Statistics); X-rays; MULTIPLE regression analysis; BONE density; INTER-observer reliability; CROSS-sectional method; DATA analysis software; DESCRIPTIVE statistics; PHOTON absorptiometry
- Publication
Rheumatology, 2016, Vol 55, Issue 3, p495
- ISSN
1462-0324
- Publication type
Article
- DOI
10.1093/rheumatology/kev377