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- Title
Usefulness of anti-cyclic citrullinated peptide antibody and rheumatoid factor to detect rheumatoid arthritis in patients with systemic sclerosis.
- Authors
Ueda-Hayakawa, Ikuko; Hasegawa, Minoru; Kumada, Sayako; Tanaka, Chihiro; Komura, Kazuhiro; Hamaguchi, Yasuhito; Takehara, Kazuhiko; Fujimoto, Manabu
- Abstract
Objectives. The purpose of this study was to determine the prevalence of anti-CCP antibodies (anti-CCP Abs) and to assess associations between the presence of anti-CCP Ab and arthritis or arthralgia in SSc patients.Methods. Serum samples were obtained from 146 SSc patients. Anti-CCP Ab, anti-agalactosyl (AG) IgG Ab, IgM-RF, IgG-RF and MMP-3 were determined, respectively.Results. The presence of anti-CCP Ab was found in 18/146 (12%) patients with SSc. Elevated levels of anti-AG IgG Abs, IgM- and IgG-RFs were observed in 50/146 (34%), 17/146 (12%) and 4/146 (3%), respectively. Serum anti-CCP Ab levels were significantly elevated in SSc–RA overlap patients compared with SSc patients with or without arthralgia (P < 0.05 or P < 0.001, respectively). Serum MMP-3 levels did not correlate with the presence of arthritis or arthralgia but were significantly associated with modified Rodnan total skin thickness score. In SSc–RA overlap patients, 10/11 (91%) patients were positive for two or more RA-related Abs.Conclusions. The serum titre of anti-CCP Ab is higher in SSc–RA overlap patients than in SSc patients with or without arthralgia. The finding of high titres of anti-CCP Abs and the elevated levels combinatory with other RA-related Abs may help to define the diagnosis of SSc–RA overlap. MMP-3 might be a better marker to assess skin involvement rather than joint involvement in SSc patients.
- Subjects
IMMUNOGLOBULIN M; IMMUNOGLOBULIN G; RHEUMATOID arthritis; JOINTS (Anatomy); RHEUMATOID factor; SKIN
- Publication
Rheumatology, 2010, Vol 49, Issue 11, p2135
- ISSN
1462-0324
- Publication type
Article
- DOI
10.1093/rheumatology/keq205