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- Title
Cross protective immune responses in nursing piglets infected with a US spike-insertion deletion porcine epidemic diarrhea virus strain and challenged with an original US PEDV strain.
- Authors
Annamalai, Thavamathi; Chun-Ming Lin; Xiang Gao; Xinsheng Liu; Zhongyan Lu; Saif, Linda J.; Qiuhong Wang
- Abstract
We investigated cross-protective immunity of a US spike-insertion deletion porcine epidemic diarrhea virus (PEDV) Iowa106 (S-INDEL) strain against the original US PEDV (PC21A) strain in nursing piglets. Piglets were inoculated orally with S-INDEL, PC21A or mock. At 20-29 days post-inoculation (dpi), all pigs were challenged with the PC21A strain. The S-INDEL-inoculated pigs had lower ileal IgA antibody secreting cells, serum IgA and neutralizing antibody titers compared with PC21A-inoculated pigs. No pigs in the PC21A-group developed diarrhea, whereas 81 and 100% of pigs in the S-INDEL and mock-groups had diarrhea post challenge, respectively. S-INDEL induced partial protective immunity against the original US PEDV strain.
- Subjects
VIRUS diseases in swine; PORCINE epidemic diarrhea virus; IMMUNE response; IMMUNOGLOBULIN A; THERAPEUTIC use of immunoglobulins
- Publication
Veterinary Research, 2017, Vol 48, p1
- ISSN
0928-4249
- Publication type
Article
- DOI
10.1186/s13567-017-0469-7