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- Title
MTHFR C677T and colorectal cancer risk: A meta-analysis of 25 populations.
- Authors
Hubner, Richard A.; Houlston, Richard S.
- Abstract
The common functional methylenetetrahydrofolate reductase ( MTHFR) C677T polymorphism may influence the risk of colorectal cancer (CRC), but data from published studies with individually low statistical power are conflicting. To clarify the role of MTHFR C677T genotype in CRC, we considered all available studies in a meta-analysis. Studies reporting on MTHFR C677T genotype and CRC were searched in PubMed up to April 2006. The principle prior hypothesis was that homozygosity for MTHFR 677TT would be associated with reduced risk of CRC. Data were available for 29,931 subjects, including 12,243 with CRC, from 25 independent populations. Compared to the homozygous CC genotype, the MTHFR 677TT genotype was associated with a reduced risk of CRC (odds ratio (OR): 0.83; 95% confidence interval (CI): 0.75-0.93; p = 0.001). There was some heterogeneity among the results of individual studies, but this was not statistically significant (heterogeneity p = 0.12; I
- Publication
International Journal of Cancer, 2007, Vol 120, Issue 5, p1027
- ISSN
0020-7136
- Publication type
Article
- DOI
10.1002/ijc.22440