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- Title
Hierarchical fluctuation shapes a dynamic flow linked to states of consciousness.
- Authors
Li, Ang; Liu, Haiyang; Lei, Xu; He, Yini; Wu, Qian; Yan, Yan; Zhou, Xin; Tian, Xiaohan; Peng, Yingjie; Huang, Shangzheng; Li, Kaixin; Wang, Meng; Sun, Yuqing; Yan, Hao; Zhang, Cheng; He, Sheng; Han, Ruquan; Wang, Xiaoqun; Liu, Bing
- Abstract
Consciousness arises from the spatiotemporal neural dynamics, however, its relationship with neural flexibility and regional specialization remains elusive. We identified a consciousness-related signature marked by shifting spontaneous fluctuations along a unimodal-transmodal cortical axis. This simple signature is sensitive to altered states of consciousness in single individuals, exhibiting abnormal elevation under psychedelics and in psychosis. The hierarchical dynamic reflects brain state changes in global integration and connectome diversity under task-free conditions. Quasi-periodic pattern detection revealed that hierarchical heterogeneity as spatiotemporally propagating waves linking to arousal. A similar pattern can be observed in macaque electrocorticography. Furthermore, the spatial distribution of principal cortical gradient preferentially recapitulated the genetic transcription levels of the histaminergic system and that of the functional connectome mapping of the tuberomammillary nucleus, which promotes wakefulness. Combining behavioral, neuroimaging, electrophysiological, and transcriptomic evidence, we propose that global consciousness is supported by efficient hierarchical processing constrained along a low-dimensional macroscale gradient. The neuroanatomical basis of consciousness is not fully understood. Here the authors show that a global state of consciousness might not depend on a specific brain region or location in Euclidean space; rather, it is linked to a low-dimensional dynamic pattern in topological space, as shown through the analysis of different experimental paradigms, imaging techniques, and species.
- Subjects
FLOW theory (Psychology); WAKEFULNESS; GENETIC transcription; CONSCIOUSNESS; NEUROPLASTICITY; BRAIN mapping; NEUROANATOMY; MENTAL arithmetic
- Publication
Nature Communications, 2023, Vol 14, Issue 1, p1
- ISSN
2041-1723
- Publication type
Article
- DOI
10.1038/s41467-023-38972-x