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- Title
Long non-coding RNA NRSN2-AS1 promotes ovarian cancer progression through targeting PTK2/β-catenin pathway.
- Authors
Wu, Yi-Bo; Li, Shen-Yi; Liu, Jin-Yan; Xue, Jia-Jia; Xu, Jin-Fu; Chen, Ting; Cao, Tian-Yue; Zhou, Hui; Wu, Tian-Tian; Dong, Chun-Lin; Qian, Wei-Feng; Qiao, Long-Wei; Hou, Shun-Yu; Wang, Ting; Shen, Cong
- Abstract
As a common malignant tumor among women, ovarian cancer poses a serious threat to their health. This study demonstrates that long non-coding RNA NRSN2-AS1 is over-expressed in ovarian cancer tissues using patient sample and tissue microarrays. In addition, NRSN2-AS1 is shown to promote ovarian cancer cell proliferation and metastasis both in vitro and in vivo. Mechanistically, NRSN2-AS1 stabilizes protein tyrosine kinase 2 (PTK2) to activate the β-catenin pathway via repressing MG-53-mediated ubiquitinated degradation of PTK2, thereby facilitating ovarian cancer progression. Rescue experiments verify the function of the NRSN2-AS1/PTK2/β-catenin axis and the effects of MG53 on this axis in ovarian cancer cells. In conclusion, this study demonstrates the key role of the NRSN2-AS1/PTK2/β-catenin axis for the first time and explores its potential clinical applications in ovarian cancer.
- Publication
Cell Death & Disease, 2023, Vol 14, Issue 10, p1
- ISSN
2041-4889
- Publication type
Article
- DOI
10.1038/s41419-023-06214-z