We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Vitamin A Status in Preterm Infants Is Associated with Inflammation and Dexamethasone Exposure.
- Authors
Rossholt, Madelaine Eloranta; Wendel, Kristina; Bratlie, Marianne; Aas, Marlen Fossan; Gunnarsdottir, Gunnthorunn; Fugelseth, Drude; Pripp, Are Hugo; Domellöf, Magnus; Størdal, Ketil; Stiris, Tom; Moltu, Sissel Jennifer
- Abstract
Vitamin A has a key role in lung development and its deficiency is associated with an increased risk of bronchopulmonary dysplasia. This secondary cohort analysis of the ImNuT trial (Immature, Nutrition Therapy NCT03555019) aimed to (1) explore vitamin A status in preterm infants <29 weeks gestation and (2) assess the influence of inflammation and postnatal dexamethasone exposure on vitamin A concentrations in blood. We report detailed information on vitamin A biochemistry, vitamin A intake, markers of inflammation and dexamethasone exposure. After four weeks of age, infants exposed to dexamethasone (n = 39) showed higher vitamin A concentrations compared to unexposed infants (n = 41); median (IQR) retinol was 1.0 (0.74, 1.5) vs. 0.56 (0.41, 0.74) µmol/L, p < 0.001. Pretreatment retinol concentrations were lower in the dexamethasone group compared to non-exposed infants (p < 0.001); 88% vs. 60% of the infants were considered deficient in vitamin A (retinol < 0.7 µmol/L) at one week of age. Small size for gestational age, mechanical ventilation and elevated levels of interleukin-6 were factors negatively associated with first-week retinol concentrations. In conclusion, preterm infants <29 weeks gestation are at risk of vitamin A deficiency despite intakes that accommodate current recommendations. The presence of inflammation and dexamethasone exposure should be considered when interpreting vitamin A status.
- Subjects
INFLAMMATION; DEXAMETHASONE; HEALTH status indicators; VITAMIN A deficiency; RESEARCH funding; BRONCHOPULMONARY dysplasia; LONGITUDINAL method; DISEASE risk factors
- Publication
Nutrients, 2023, Vol 15, Issue 2, p441
- ISSN
2072-6643
- Publication type
Article
- DOI
10.3390/nu15020441