We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Acute Effects of Cocoa Flavanols on Blood Pressure and Peripheral Vascular Reactivity in Type 2 Diabetes Mellitus and Essential Hypertension.
- Authors
Tanghe, Anouk; Heyman, Elsa; Lespagnol, Elodie; Stautemas, Jan; Celie, Bert; Op 't Roodt, Jos; Rietzschel, Ernst; Dias Soares, Danusa; Hermans, Nina; Tuenter, Emmy; Shadid, Samyah; Calders, Patrick
- Abstract
Background: Type 2 diabetes mellitus (T2DM) is associated with a high risk of vascular complications. Interestingly, cocoa flavanols (CF) can exert beneficial vascular effects in non-diabetic subjects. However, these effects have only been scarcely studied in T2DM. Therefore, we performed a study to assess the effects on vascular reactivity of a single dose of CF (790 mg) in T2DM and whether certain antihypertensive drugs may modulate these effects. Methods: 24 non-diabetic and 11 T2DM subjects were studied in a cross-over design. Fasting blood samples, blood pressure (BP), and arterial vasoreactivity (flow-mediated dilation) were assessed before and 70 min after capsule ingestion. Muscle microvascular reactivity was only assessed after capsule ingestion. Age, waist-to-hip ratio, BP at baseline, and the use of antihypertensive drugs were regarded as covariates in a mixed models analysis. Results: CF ingestion did not affect any parameter. However, independent of the type of capsules ingested, a decrease in diastolic BP by 3 mmHg (95% CI: −4.0; −2.0) and an increase in the change in brachial artery diameter (pre vs. post occlusion) by 0.06 mm (95% CI: 0.01; 0.12) were detected in the non-diabetic group, while they remained unchanged in the T2DM group. Conclusion: No beneficial effects of CF were detected on vascular reactivity parameters in T2DM and non-diabetic participants.
- Subjects
MUSCLE physiology; ANTIHYPERTENSIVE agents; FASTING; BLOOD pressure; FLAVONOIDS; BRACHIAL artery; CONFIDENCE intervals; ARTERIES; CACAO; BLOOD collection; TYPE 2 diabetes; VASODILATION; RANDOMIZED controlled trials; CROSSOVER trials; PHARMACODYNAMICS
- Publication
Nutrients, 2022, Vol 14, Issue 13, p2692
- ISSN
2072-6643
- Publication type
Article
- DOI
10.3390/nu14132692