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- Title
Impact of Infectious Disease after Lactococcus lactis Strain Plasma Intake in Vietnamese Schoolchildren: A Randomized, Placebo-Controlled, Double-Blind Study.
- Authors
Thu, Nghiem Nguyet; Mai, Truong Tuyet; Trang, Tran Thị Thu; Tuan, Nguyen Anh; Quyen, Tran Chau; Hanh, Nguyen Lien; Hoan, Nguyen Huu; Lan, Bui Thi Huong; Hau, Phung Thi; Tue, Ha Huy; Dung, Truong Viet; Tsuji, Ryohei; Watanabe, Yuta; Yamamoto, Naoki; Kanauchi, Osamu
- Abstract
Lactococcus lactis strain Plasma (LC-Plasma) is reported to have anti-viral effects via direct activation of plasmacytoid dendritic cells, which upregulate the production of type I and III interferons. A randomized, placebo-controlled, double-blind, parallel group study was designed for elementary schoolchildren, grades 1 to 3, in Vietnam. LC-Plasma or a control were administered to schoolchildren as a beverage (1.0 × 1011 count LC-Plasma/day/person). The primary endpoint was to determine the efficacy of LC-Plasma in reducing the cumulative days absent from school due to upper respiratory disease (URID) and gastrointestinal disease (GID), and the secondary endpoint was to evaluate the potency of LC-Plasma on URID/GID symptoms and general well-being scores. LC-Plasma intake significantly reduced the cumulative days absent from school due to URID/GID (Odds ratio (OR) = 0.57, p = 0.004) and URID alone (OR = 0.56, p = 0.005); LC-Plasma also significantly reduced the number of cumulative fever positive days during the first 4 weeks of intervention (OR = 0.58, p = 0.001) and cumulative days with diarrhea during the last 4 weeks of the intervention period (OR = 0.78, p = 0.01). The number of positive general wellbeing days was significantly improved in the LC-Plasma group compared with the control throughout the intervention period (OR = 0.93, 0.93, p = 0.03, 0.04 in the first and last 4 weeks of the intervention, respectively). These data suggest that LC-Plasma seems to improve the health condition of elementary schoolchildren and reduces school absenteeism due to infectious disease, especially URID.
- Subjects
VIETNAM; COMMUNICABLE diseases; SCHOOL health services; CONFIDENCE intervals; RANDOMIZED controlled trials; BLIND experiment; STATISTICAL sampling; ODDS ratio; DISEASE complications; CHILDREN
- Publication
Nutrients, 2022, Vol 14, Issue 3, p552
- ISSN
2072-6643
- Publication type
Article
- DOI
10.3390/nu14030552