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- Title
Effect and Tolerability of a Nutritional Supplement Based on a Synergistic Combination of β-Glucans and Selenium- and Zinc-Enriched Saccharomyces cerevisiae (ABB C1 ®) in Volunteers Receiving the Influenza or the COVID-19 Vaccine: A Randomized, Double-Blind, Placebo-Controlled Study
- Authors
Rodriguez, Julián Andrés Mateus; Bifano, Mónica; Roca Goma, Elvira; Plasencia, Carlos Méndez; Torralba, Anna Olivé; Font, Mercè Santó; Millán, Pedro Roy
- Abstract
A single-center, randomized, double-blind, placebo-controlled study was conducted in 72 volunteers who received a synergistic combination of yeast-based ingredients with a unique β-1,3/1,6-glucan complex and a consortium of heat-treated probiotic Saccharomyces cerevisiae rich in selenium and zinc (ABB C1®) or placebo on the next day after getting vaccinated against influenza (Chiromas®) (n = 34) or the COVID-19 (Comirnaty®) (n = 38). The duration of treatment was 30 and 35 days for the influenza and COVID-19 vaccine groups, respectively. Mean levels of CD4+T cells increased from 910.7 at baseline to 1000.2 cells/µL after the second dose of the COVID-19 vaccine in the ABB C1® group, whereas there was a decrease from 1055.1 to 929.8 cells/µL in the placebo group. Changes of CD3+T and CD8+T lymphocytes showed a similar trend. In the COVID-19 cohort, the increases in both IgG and IgM were higher in the ABB C1® supplement than in the placebo group. Serum levels of selenium and zinc showed a higher increase in subjects treated with the active product than in those receiving placebo. No serious adverse events related to ABB C1® or tolerance issues were reported. The study findings validate the capacity of the ABB C1® product to stimulate trained immunity.
- Subjects
BIOMARKERS; NUTRITIONAL assessment; IMMUNOGLOBULINS; COVID-19 vaccines; GLUCANS; DIETARY supplements; PROBIOTICS; RANDOMIZED controlled trials; CD4 lymphocyte count; MESSENGER RNA; RESEARCH funding; SELENIUM
- Publication
Nutrients, 2021, Vol 13, Issue 12, p4347
- ISSN
2072-6643
- Publication type
Article
- DOI
10.3390/nu13124347