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- Title
Schisandra Extract and Ascorbic Acid Synergistically Enhance Cognition in Mice through Modulation of Mitochondrial Respiration.
- Authors
Jang, Yunseon; Lee, Jae Hyeon; Lee, Min Joung; Kim, Soo Jeong; Ju, Xianshu; Cui, Jianchen; Zhu, Jiebo; Lee, Yu Lim; Namgung, Eunji; Sung, Han Wool John; Lee, Hong Won; Ryu, Min Jeong; Oh, Eungseok; Chung, Woosuk; Kweon, Gi Ryang; Choi, Chun Whan; Heo, Jun Young
- Abstract
Cognitive decline is observed in aging and neurodegenerative diseases, including Alzheimer's disease (AD) and dementia. Intracellular energy produced via mitochondrial respiration is used in the regulation of synaptic plasticity and structure, including dendritic spine length and density, as well as for the release of neurotrophic factors involved in learning and memory. To date, a few synthetic agents for improving mitochondrial function have been developed for overcoming cognitive impairment. However, no natural compounds that modulate synaptic plasticity by directly targeting mitochondria have been developed. Here, we demonstrate that a mixture of Schisandra chinensis extract (SCE) and ascorbic acid (AA) improved cognitive function and induced synaptic plasticity-regulating proteins by enhancing mitochondrial respiration. Treatment of embryonic mouse hippocampal mHippoE-14 cells with a 4:1 mixture of SCE and AA increased basal oxygen consumption rate. We found that mice injected with the SCE-AA mixture showed enhanced learning and memory and recognition ability. We further observed that injection of the SCE-AA mixture in mice significantly increased expression of postsynaptic density protein 95 (PSD95), an increase that was correlated with enhanced brain-derived neurotrophic factor (BDNF) expression. These results demonstrate that a mixture of SCE and AA improves mitochondrial function and memory, suggesting that this natural compound mixture could be used to alleviate AD and aging-associated memory decline.
- Subjects
MITOCHONDRIAL physiology; ALZHEIMER'S disease; ANIMAL experimentation; COGNITION; HIPPOCAMPUS (Brain); MEMORY; MICE; NEURODEGENERATION; NEUROPLASTICITY; VITAMIN C; PLANT extracts; OXYGEN consumption; BRAIN-derived neurotrophic factor
- Publication
Nutrients, 2020, Vol 12, Issue 4, p897
- ISSN
2072-6643
- Publication type
Article
- DOI
10.3390/nu12040897