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- Title
The Dietary Inflammatory Index and Chronic Lymphocytic Leukaemia in the MCC Spain Study.
- Authors
Flores, José Carlos; Gracia-Lavedan, Esther; Benavente, Yolanda; Amiano, Pilar; Romaguera, Dora; Costas, Laura; Robles, Claudia; Gonzalez-Barca, Eva; de la Banda, Esmeralda; Alonso, Esther; Aymerich, Marta; Campo, Elias; Dierssen-Sotos, Trinidad; Marcos-Gragera, Rafael; Rodriguez-Suarez, Marta María; Solans, Marta; Gimeno, Eva; Garcia Martin, Paloma; Aragones, Nuria; Shivappa, Nitin
- Abstract
Chronic inflammation plays a role in the development of chronic lymphocytic leukaemia (CLL), and diet might modulate chronic inflammation. This study aims to evaluate the association between the dietary inflammatory index (DII®) and CLL. A total of 366 CLL cases and 1643 controls of the Spanish multicase-control (MCC) Spain study were included. The inflammatory potential of the diet was assessed using the energy-adjusted dietary inflammatory index (E-DII) based on 30 items from a validated semi-quantitative food frequency questionnaire. Odds ratios (OR) and 95% confidence intervals (CI) were estimated using logistic regression models controlling for potential confounders. Overall, a modest, non-statistically significant, positive association was observed between CLL and E-DII scores (OR for a one-unit increase in E-DII: 1.05 (CI 95%: 0.99, 1.12), p-value = 0.09 and by tertiles: ORT2vsT1: 1.20 (CI 95%: 0.90, 1.59); OR T3vsT1: 1.21 (CI 95%: 0.90, 1.62), p trend = 0.21). These results were independent from disease severity (p-het: 0.70), time from diagnosis (p-het: 0.67) and CLL treatment received (p-het: 0.56). No interactions were detected. In conclusion, the consumption of a diet with high pro-inflammatory components was not significantly associated with CLL. Changes towards a more pro-inflammatory dietary pattern in younger generations not included here warrant future research.
- Subjects
CHRONIC lymphocytic leukemia; CONFIDENCE intervals; DIET; INFLAMMATION; HEALTH outcome assessment; QUESTIONNAIRES; RISK assessment; LOGISTIC regression analysis; CASE-control method; DATA analysis software; DESCRIPTIVE statistics; ODDS ratio; DISEASE complications
- Publication
Nutrients, 2020, Vol 12, Issue 1, p48
- ISSN
2072-6643
- Publication type
Article
- DOI
10.3390/nu12010048