We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Walnut Polyphenol Extract Protects against Fenitrothion-Induced Immunotoxicity in Murine Splenic Lymphocytes.
- Authors
Liu, Hong; Wan, Yifang; Wang, Yuxin; Zhao, Yue; Zhang, Yue; Zhang, Ao; Weng, Qiang; Xu, Meiyu
- Abstract
Fenitrothion (FNT), an organophosphate pesticide, exerts an immunotoxic effect on splenocytes. Dietary polyphenol compounds exert antioxidant, anticancer and antihypertensive effects. In this study, we investigated the effect of walnut polyphenol extract (WPE) on FNT-induced immunotoxicity in splenic lymphocytes in vitro. Treatment with WPE significantly increased the proliferation of FNT-exposed splenocytes, as evidenced by increases in the proportions of splenic T lymphocytes (CD3+ T cells) and T-cell subsets (CD8+ T cells), as well as the secretion of the T-cell-related cytokines interleukin (IL)-2, interferon-γ, IL-4 and granzyme B. These effects were associated with a reduction in oxidative stress, as evidenced by changes in the levels of hydroxyl radical, superoxide dismutase, glutathione peroxidase and malondialdehyde. Moreover, WPE decreased the FNT-induced overexpression of NADPH oxidase 2 and dual oxidase 1 by regulating Toll-like receptor 4 signaling in splenic T-cells. Taken together, these findings suggest that WPE protects against FNT-mediated immunotoxicity and improves immune function by inhibiting oxidative stress.
- Subjects
CELL proliferation; ANTIGENS; CELLULAR signal transduction; CYTOKINES; GENE expression; GLUTATHIONE; HYDROXIDES; IMMUNE system; IMMUNOLOGIC diseases; INTERFERONS; INTERLEUKIN-2; LYMPHOCYTES; MICE; OXIDOREDUCTASES; PEROXIDASE; POLYPHENOLS; PROTEOLYTIC enzymes; SPLEEN; SUPEROXIDE dismutase; T cells; WALNUT; MALONDIALDEHYDE; OXIDATIVE stress; ORGANOTHIOPHOSPHORUS compounds; TOLL-like receptors
- Publication
Nutrients, 2018, Vol 10, Issue 12, p1838
- ISSN
2072-6643
- Publication type
Article
- DOI
10.3390/nu10121838