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- Title
Postmenopausal estrogen use and coronary atherosclerosis.
- Authors
Sullivan, Jay M.; Zwaag, Roger Vander; Lemp, George F.; Hughes, Jeff P.; Maddock, Virginia; Kroetz, Frank W.; Ramanathan, K.B.; Mirvis, David M.; Sullivan, J M; Vander Zwaag, R; Lemp, G F; Hughes, J P; Maddock, V; Kroetz, F W; Mirvis, D M
- Abstract
<bold>Study Objective: </bold>To determine whether estrogen replacement therapy affects the prevalence of severely obstructive coronary arterial lesions defined by selective coronary arteriography.<bold>Design: </bold>Case-control study.<bold>Setting: </bold>Large, urban, university-affiliated referral hospital.<bold>Patients: </bold>From a consecutive sample of 6452 women having coronary arteriography between 1972 and 1984, 2188 patients were eligible for study; others were excluded because they were nonmenopausal, had congenital heart defects, valvular heart disorders, primary myocardial disease, or no more than mild to moderate coronary artery disease.<bold>Interventions: </bold>None.<bold>Measurements and Main Results: </bold>Hospital nurses routinely obtained medication histories. Staff invasive cardiologists interpreted coronary arteriograms. Clinical, laboratory, and angiographic data were abstracted from the cardiac catheterization reports and entered into a computerized registry. Postmenopausal estrogen use for 1444 cases of coronary artery disease (70% stenosis) was compared to that 744 controls (0% stenosis). The odds ratio estimate of the risk of coronary artery disease for estrogen users relative to the risk of coronary artery disease for nonusers was 0.44 (95% confidence interval, 0.29 to 0.67) after adjustment for age, cigarette smoking, diabetes, cholesterol, and hypertension. Postmenopausal estrogen replacement was a significant independent protective factor for coronary artery disease in a multivariate logistic regression model (P = 0.037).<bold>Conclusion: </bold>The data suggest that postmenopausal estrogen treatment reduces the risk for angiographically significant coronary artery disease.
- Subjects
ESTROGEN replacement therapy; ARTERIOGRAPHY; HORMONE therapy for menopause; CORONARY heart disease prevention; AGE distribution; CHOLESTEROL; CORONARY disease; MENOPAUSE; SMOKING; RETROSPECTIVE studies; CORONARY angiography
- Publication
Annals of Internal Medicine, 1988, Vol 108, Issue 3, p358
- ISSN
0003-4819
- Publication type
journal article
- DOI
10.7326/0003-4819-108-3-358