We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Exposure to human T-lymphotropic virus type III/lymphadenopathy-associated virus and immunologic abnormalities in asymptomatic homosexual men.
- Authors
Nicholson, Janet K.A.; McDougal, J. Steven; Jaffe, Harold W.; Spira, Thomas J.; Kennedy, M. Susan; Jones, Bonnie M.; Darrow, William W.; Morgan, Meade; Hubbard, Marjorie; Nicholson, J K; McDougal, J S; Jaffe, H W; Spira, T J; Kennedy, M S; Jones, B M; Darrow, W W; Morgan, M; Hubbard, M
- Abstract
Immunologic and serologic studies were done in 120 homosexual men who reportedly had no symptoms related to the acquired immunodeficiency syndrome. Forty-nine men (41%) had antibody to the retrovirus human T-lymphotropic virus type III/lymphadenopathy-associated virus (HTLV-III/LAV), and 37 (31%) had an abnormal T-cell subset ratio and other immunologic abnormalities. These abnormalities were almost exclusively confined to men seropositive for the retrovirus. Multivariate statistical analysis showed that exposure to HTLV-III/LAV was the single best predictor of T-cell (and other) immunologic abnormalities. Sexual practice, particularly receptive anal intercourse, predicted exposure to HTLV-III/LAV but was not independently related to T-cell abnormalities. The association of other microbial serologic findings with HTLV-III/LAV seropositivity or T-cell changes was a coincidental function of sexual activity. Immunologic abnormalities in asymptomatic homosexual men are mostly related to exposure to HTLV-III/LAV.
- Subjects
HIV; HIV infections; HEALTH of gay men; ANAL sex
- Publication
Annals of Internal Medicine, 1985, Vol 103, Issue 1, p37
- ISSN
0003-4819
- Publication type
journal article
- DOI
10.7326/0003-4819-103-1-37